Naporafenib (LXH254)
Naporafenib (LXH254) is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays.
Trivial name | N/A |
Catalog Number | S8745 |
Molecular Formula | C25H25F3N4O4 |
CAS# | 1800398-38-2 |
Inchi | InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34) |
Inchi Key | UEPXBTCUIIGYCY-UHFFFAOYSA-N |
SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=NC=C2)C(F)(F)F)C3=CC(=NC(=C3)OCCO)N4CCOCC4 |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/lxh254.html |
Additional Information | https://file.selleck.cn/downloads/struct/lxh254-chemical-structure-s8745.gif |