Selective JAK3 inhibitor 1
Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.
Trivial name | N/A |
Catalog Number | S8684 |
Molecular Formula | C19H18N4O3 |
CAS# | 1443235-95-7 |
Inchi | InChI=1S/C19H18N4O3/c1-4-26-19(25)14-9-20-17-15(14)16(21-10-22-17)12-6-5-7-13(8-12)23-18(24)11(2)3/h5-10H,2,4H2,1,3H3,(H,23,24)(H,20,21,22) |
Inchi Key | NJPHKVOXHRAPGJ-UHFFFAOYSA-N |
SMILES | CCOC(=O)C1=CNC2=NC=NC(=C12)C3=CC(=CC=C3)NC(=O)C(=C)C |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/selective-jak3-inhibitor-1.html |
Additional Information | https://file.selleck.cn/downloads/struct/selective-jak3-inhibitor-1-chemical-structure-s8684.gif |