PF-06840003
PF-06840003 (EOS200271) is a highly selective orally bioavailable IDO-1 inhibitor. Although it has moderate hIDO1 enzyme inhibition (IC50 0.41 μM), it is a highly efficient compound (LE 0.53, LipE 5.1), driven by its tight packing within the enzyme, as well as the high density of hydrogen bonds it forms with hIDO-1 despite its small size.
| Trivial name | EOS200271 |
| Catalog Number | S8657 |
| Molecular Formula | C12H9FN2O2 |
| CAS# | 198474-05-4 |
| Inchi | InChI=1S/C12H9FN2O2/c13-6-1-2-10-7(3-6)9(5-14-10)8-4-11(16)15-12(8)17/h1-3,5,8,14H,4H2,(H,15,16,17) |
| Inchi Key | MXKLDYKORJEOPR-UHFFFAOYSA-N |
| SMILES | C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/pf-06840003.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-06840003-chemical-structure-s8657.gif |