BML-277 (Chk2 Inhibitor II)

BML-277 (Chk2 Inhibitor II) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. Chk2 Inhibitor II (BML-277) dose dependently protects human CD4(+) and CD8(+) T-cells from apoptosis due to ionizing radiation.

Price Not Available 5mg BML-277 (Chk2 Inhibitor II) Supplier Page

Trivial name	N/A
Catalog Number	S8632
Molecular Formula	C20H14ClN3O2
CAS#	516480-79-8
Inchi	InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
Inchi Key	UXGJAOIJSROTTN-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
Size	5mg
Supplier Page	http://www.selleckchem.com/products/chk2-inhibitor-2-bml-277.html
Additional Information	https://file.selleck.cn/downloads/struct/chk2-inhibitor-2-bml-277-chemical-structure-s8632.gif