DCA (Sodium dichloroacetate)
DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
Trivial name | Dichloroacetic acid, bichloroacetic acid, BCA |
Catalog Number | S8615 |
Molecular Formula | C2HCl2O2.Na |
CAS# | 2156-56-1 |
Inchi | InChI=1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1 |
Inchi Key | LUPNKHXLFSSUGS-UHFFFAOYSA-M |
SMILES | C(C(=O)[O-])(Cl)Cl.[Na+] |
Size | 100mg |
Supplier Page | http://www.selleckchem.com/products/sodium-dichloroacetate-dca.html |
Additional Information | https://file.selleck.cn/downloads/struct/sodium-dichloroacetate-dca-chemical-structure-S8615.gif |