PF-06726304
PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM.
| Trivial name | PF-6726304 |
| Catalog Number | S8494 |
| Molecular Formula | C22H21Cl2N3O3 |
| CAS# | 1616287-82-1 |
| Inchi | InChI=1S/C22H21Cl2N3O3/c1-10-7-11(2)25-21(28)16(10)9-27-6-5-14-17(23)8-15(20(24)19(14)22(27)29)18-12(3)26-30-13(18)4/h7-8H,5-6,9H2,1-4H3,(H,25,28) |
| Inchi Key | PDKDOPJQPKXNCT-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)C4=C(ON=C4C)C)Cl)C |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/pf-06726304.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-06726304-chemical-structure-s8494.gif |