Fenebrutinib (GDC-0853)

Fenebrutinib (GDC-0853) is a potent, selective, and non-covalent bruton’s tyrosine kinase (BTK) inhibitor with an Ki value of 0.91 nM for Btk with >100-fold selectivity over 3 off-targets (Bmx :153-fold, Fgr: 168-fold, Src:131-fold).

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Trivial name	N/A
Catalog Number	S8421
Molecular Formula	C37H44N8O4
CAS#	1434048-34-6
Inchi	InChI=1S/C37H44N8O4/c1-23-18-42(27-21-49-22-27)9-10-43(23)26-5-6-33(39-17-26)40-30-13-25(19-41(4)35(30)47)28-7-8-38-34(29(28)20-46)45-12-11-44-31(36(45)48)14-24-15-37(2,3)16-32(24)44/h5-8,13-14,17,19, 23,27,46H,9-12,15-16,18,20-22H2,1-4H3,(H,39,40)/t23-/m0/s1
Inchi Key	WNEODWDFDXWOLU-QHCPKHFHSA-N
SMILES	CC1CN(CCN1C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=NC=C4)N5CCN6C7=C(CC(C7)(C)C)C=C6C5=O)CO)C8COC8
Size	5mg
Supplier Page	http://www.selleckchem.com/products/fenebrutinib-gdc-0853.html
Additional Information	https://file.selleck.cn/downloads/struct/fenebrutinib-gdc-0853-chemical-structure-s8421.gif