PACAP 6-38 acetate
PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.
Trivial name | N/A |
Catalog Number | S8416 |
Molecular Formula | C182H300N56O45S |
CAS# | 143748-18-9(free base) |
Inchi | InChI=1S/C182H300N56O45S/c1-95(2)83-128(211-141(249)92-207-152(257)114(39-19-26-71-183)212-156(261)120(46-33-78-203-179(194)195)217-167(272)130(86-105-50-58-109(242)59-51-105)226-160(265)117(42-22-29- 74-186)215-162(267)124(66-68-138(191)246)221-158(263)123(49-36-81-206-182(200)201)224-177(282)145(99(9)10)236-164(269)119(44-24-31-76-188)216-171(276)134(90-140(193)248)230-165(270)127(238-202)45-25-3 2-77-189)173(278)234-143(97(5)6)148(253)147(252)100(11)208-149(254)101(12)210-166(271)129(84-96(3)4)225-169(274)132(88-107-54-62-111(244)63-55-107)228-159(264)116(41-21-28-73-185)214-155(260)118(43-23 -30-75-187)223-176(281)144(98(7)8)235-150(255)102(13)209-153(258)126(70-82-284-15)222-163(268)125(67-69-139(192)247)220-154(259)115(40-20-27-72-184)213-157(262)121(47-34-79-204-180(196)197)218-168(273 )131(87-106-52-60-110(243)61-53-106)227-161(266)122(48-35-80-205-181(198)199)219-174(279)136(93-239)232-170(275)133(89-108-56-64-112(245)65-57-108)229-175(280)137(94-240)233-172(277)135(91-142(250)251 )231-178(283)146(103(14)241)237-151(256)113(190)85-104-37-17-16-18-38-104/h16-18,37-38,50-65,95-103,113-137,143-146,238-245H,19-36,39-49,66-94,183-190,202H2,1-15H3,(H2,191,246)(H2,192,247)(H2,193,248) (H,207,257)(H,208,254)(H,209,258)(H,210,271)(H,211,249)(H,212,261)(H,213,262)(H,214,260)(H,215,267)(H,216,276)(H,217,272)(H,218,273)(H,219,279)(H,220,259)(H,221,263)(H,222,268)(H,223,281)(H,224,282)(H ,225,274)(H,226,265)(H,227,266)(H,228,264)(H,229,280)(H,230,270)(H,231,283)(H,232,275)(H,233,277)(H,234,278)(H,235,255)(H,236,269)(H,237,256)(H,250,251)(H4,194,195,203)(H4,196,197,204)(H4,198,199,205) (H4,200,201,206)/t100-,101-,102-,103+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,143+,144+,145+,146+/m1/s1 |
Inchi Key | WMDBEYPMPCBLRH-ITVNAFMISA-N |
SMILES | CSCCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(N)CC3=CC=CC=C3)C(C)O)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC4=CC=C(O)C=C4)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC5=CC=C(O)C=C5)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(N)=O |
Size | 1mg |
Supplier Page | http://www.selleckchem.com/products/pacap-6-38.html |
Additional Information | https://file.selleck.cn/downloads/struct/pacap-6-38-chemical-structure-S8416.gif |