RSL3
RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.
| Trivial name | (1S,3R)-RSL3 |
| Catalog Number | S8155 |
| Molecular Formula | C23H21ClN2O5 |
| CAS# | 1219810-16-8 |
| Inchi | InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1 |
| Inchi Key | TXJZRSRTYPUYRW-NQIIRXRSSA-N |
| SMILES | COC(=O)C1CC2=C(C(N1C(=O)CCl)C3=CC=C(C=C3)C(=O)OC)NC4=CC=CC=C24 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/rsl3.html |
| Additional Information | https://file.selleck.cn/downloads/struct/rsl3-chemical-structure-s8155.gif |