PD0166285
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S8148 |
| Molecular Formula | C26H27Cl2N5O2 |
| CAS# | 185039-89-8 |
| Inchi | InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31) |
| Inchi Key | IFPPYSWJNWHOLQ-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/pd0166285.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pd0166285-chemical-structure-s8148.gif |