Necrostatin-1
Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.
| Trivial name | Nec-1 |
| Catalog Number | S8037 |
| Molecular Formula | C13H13N3OS |
| CAS# | 4311-88-0 |
| Inchi | InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18) |
| Inchi Key | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
| SMILES | CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/necrostatin-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Necrostatin-1-chemical-structure-s8037.gif |