VE-821
VE-821(ATR inhibitor IV) is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.
| Trivial name | ATR inhibitor IV |
| Catalog Number | S8007 |
| Molecular Formula | C18H16N4O3S |
| CAS# | 1232410-49-9 |
| Inchi | InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23) |
| Inchi Key | DUIHHZKTCSNTGM-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/ve-821.html |
| Additional Information | https://file.selleck.cn/downloads/struct/VE-821-chemical-structure-s8007.gif |