NVP-CGM097
NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.
| Trivial name | CGM-097 |
| Catalog Number | S7875 |
| Molecular Formula | C38H47ClN4O4 |
| CAS# | 1313363-54-0 |
| Inchi | InChI=1S/C38H47ClN4O4/c1-25(2)47-35-22-33-28(20-34(35)46-5)21-36(44)43(38(33)27-8-10-29(39)11-9-27)32-16-14-30(15-17-32)41(4)23-26-6-12-31(13-7-26)42-19-18-40(3)37(45)24-42/h8-11,14-17,20,22,25-26,31, 38H,6-7,12-13,18-19,21,23-24H2,1-5H3/t26-,31-,38-/m0/s1 |
| Inchi Key | CLRSLRWKONPSRQ-IIPSPAQQSA-N |
| SMILES | CC(C)OC1=C(C=C2CC(=O)N(C(C2=C1)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)N(C)CC5CCC(CC5)N6CCN(C(=O)C6)C)OC |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/nvp-cgm097.html |
| Additional Information | https://file.selleck.cn/downloads/struct/nvp-cgm097-chemical-structure-s7875.gif |