Brilanestrant (GDC-0810)

Brilanestrant (GDC-0810, ARN-810） is a potent ER-α binder (ER-α, IC50 = 6.1 nM; ER-β, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-α degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.

Price Not Available 5mg Brilanestrant (GDC-0810) Supplier Page

Trivial name	ARN-810
Catalog Number	S7855
Molecular Formula	C26H20ClFN2O2
CAS#	1365888-06-7
Inchi	InChI=1S/C26H20ClFN2O2/c1-2-21(22-10-9-20(28)14-23(22)27)26(18-8-11-24-19(13-18)15-29-30-24)17-6-3-16(4-7-17)5-12-25(31)32/h3-15H,2H2,1H3,(H,29,30)(H,31,32)/b12-5+,26-21+
Inchi Key	BURHGPHDEVGCEZ-KJGLQBJMSA-N
SMILES	CCC(=C(C1=CC=C(C=C1)C=CC(=O)O)C2=CC3=C(C=C2)NN=C3)C4=C(C=C(C=C4)F)Cl
Size	5mg
Supplier Page	http://www.selleckchem.com/products/brilanestrant-gdc-0810-arn-810.html
Additional Information	https://file.selleck.cn/downloads/struct/gdc-0810-chemical-structure-s7855.gif