BI-847325
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
| Trivial name | N/A |
| Catalog Number | S7843 |
| Molecular Formula | C29H28N4O2 |
| CAS# | 1207293-36-4 |
| Inchi | InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8-6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30,34)(H,32,35)/b28-27- |
| Inchi Key | FLBNLJLONKAPLR-DQSJHHFOSA-N |
| SMILES | CCNC(=O)C#CC1=CC2=C(C=C1)C(=C(N2)O)C(=NC3=CC=C(C=C3)CN(C)C)C4=CC=CC=C4 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/bi-847325.html |
| Additional Information | https://file.selleck.cn/downloads/struct/bi-847325-chemical-structure-s7843.gif |