Dorsomorphin
Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble S7306 Dorsomorphin (Compound C) 2HCl is recommended.
| Trivial name | BML-275,Compound C |
| Catalog Number | S7840 |
| Molecular Formula | C24H25N5O |
| CAS# | 866405-64-3 |
| Inchi | InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 |
| Inchi Key | XHBVYDAKJHETMP-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/dorsomorphin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/dorsomorphin-chemical-structure-s7840.gif |