TH588
TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
| Trivial name | N/A |
| Catalog Number | S7632 |
| Molecular Formula | C13H12Cl2N4 |
| CAS# | 1609960-31-7 |
| Inchi | InChI=1S/C13H12Cl2N4/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10/h1-3,6-7H,4-5H2,(H3,16,17,18,19) |
| Inchi Key | PNMYJIOQIAEYQL-UHFFFAOYSA-N |
| SMILES | C1CC1NC2=NC(=NC(=C2)C3=C(C(=CC=C3)Cl)Cl)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/th588.html |
| Additional Information | https://file.selleck.cn/downloads/struct/th588-chemical-structure-s7632.gif |