Doravirine
Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities.
| Trivial name | MK-1439 |
| Catalog Number | S6492 |
| Molecular Formula | C17H11C1F3N5O3 |
| CAS# | 1338225-97-0 |
| Inchi | InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28) |
| Inchi Key | ZIAOVIPSKUPPQW-UHFFFAOYSA-N |
| SMILES | CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/doravirine-mk-1439.html |
| Additional Information | https://file.selleck.cn/downloads/struct/doravirine-chemical-structure-s6492.gif |