Altiratinib
Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM.
| Trivial name | DCC-2701 |
| Catalog Number | S6412 |
| Molecular Formula | C26H21F3N4O4 |
| CAS# | 1345847-93-9 |
| Inchi | InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34) |
| Inchi Key | GNNDEPIMDAZHRQ-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/altiratinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/altiratinib-chemical-structure-s6412.gif |