acalisib (GS-9820)
Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.
Trivial name | CAL-120 |
Catalog Number | S5818 |
Molecular Formula | C21H16FN7O |
CAS# | 870281-34-8 |
Inchi | InChI=1S/C21H16FN7O/c1-12(27-19-17-18(24-10-23-17)25-11-26-19)20-28-16-8-7-13(22)9-15(16)21(30)29(20)14-5-3-2-4-6-14/h2-12H,1H3,(H2,23,24,25,26,27)/t12-/m0/s1 |
Inchi Key | DOCINCLJNAXZQF-LBPRGKRZSA-N |
SMILES | CC(C1=NC2=C(C=C(C=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/acalisib-gs-9820.html |
Additional Information | https://file.selleck.cn/downloads/struct/acalisib-gs-9820-chemical-structure-s5818.gif |