Toceranib phosphate
Toceranib phosphate (Palladia, SU11654), the phosphate salt of toceranib, is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR, and Kit with Ki values of 6 nM and 5 nM for Flk-1/KDR and PDGFRβ, respectively.
Trivial name | Palladia, SU11654 |
Catalog Number | S5272 |
Molecular Formula | C22H25FN4O2.H3O4P |
CAS# | 874819-74-6 |
Inchi | InChI=1S/C22H25FN4O2.H3O4P/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27;1-5(2,3)4/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28);(H3,1,2,3,4)/b17-12-; |
Inchi Key | AOORBROPMMRREB-HBPAQXCTSA-N |
SMILES | CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)C=C3C4=C(C=CC(=C4)F)NC3=O.OP(=O)(O)O |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/toceranib-phosphate.html |
Additional Information | https://file.selleck.cn/downloads/struct/toceranib-phosphate-chemical-structure-s5272.gif |