Apatinib
Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis.
| Trivial name | Rivoceranib, YN968D1 |
| Catalog Number | S5248 |
| Molecular Formula | C28H36O10 |
| CAS# | 811803-05-1 |
| Inchi | InChI=1S/C28H36O10/c1-17-4-7-20-27(2,19(17)6-5-18-13-15-36-26(18)35)14-12-21(38-25(34)11-9-23(31)32)28(20,3)16-37-24(33)10-8-22(29)30/h5-6,13,19-21H,1,4,7-12,14-16H2,2-3H3,(H,29,30)(H,31,32)/b6-5+/t19 -,20+,21-,27+,28+/m1/s1 |
| Inchi Key | YTHKMAIVPFVDNU-GPTWTFMPSA-N |
| SMILES | CC12CCC(C(C1CCC(=C)C2C=CC3=CCOC3=O)(C)COC(=O)CCC(=O)O)OC(=O)CCC(=O)O |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/apatinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/apatinib-chemical-structure-s5248.gif |