Apatinib
Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis.
| Trivial name | Rivoceranib, YN968D1 |
| Catalog Number | S5248 |
| Molecular Formula | C24H39NO5 |
| CAS# | 811803-05-1 |
| Inchi | InChI=1S/C24H39NO5/c1-5-25-11-22(12-28-2)7-6-18(30-4)24-14-8-13-16(29-3)10-23(27,19(14)20(13)26)15(21(24)25)9-17(22)24/h13-21,26-27H,5-12H2,1-4H3/t13-,14-,15+,16+,17-,18+,19-,20+,21?,22+,23+,24-/m1/s1 |
| Inchi Key | BDCURAWBZJMFIK-FLDLCTCNSA-N |
| SMILES | CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5C6O)OC)O)OC)COC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/apatinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/apatinib-chemical-structure-s5248.gif |