Ruxolitinib Phosphate

Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

Price Not Available 100mg Ruxolitinib Phosphate Supplier Page

Trivial name	INCB018424, INC424
Catalog Number	S5243
Molecular Formula	C17H18N6.H3O4P
CAS#	1092939-17-7
Inchi	InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1
Inchi Key	JFMWPOCYMYGEDM-XFULWGLBSA-N
SMILES	C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
Size	100mg
Supplier Page	http://www.selleckchem.com/products/ruxolitinib-phosphate.html
Additional Information	https://file.selleck.cn/downloads/struct/ruxolitinib-phosphate-chemical-structure-s5243.gif