SC-514
SC-514 (GK 01140) is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
| Trivial name | GK 01140 |
| Catalog Number | S4907 |
| Molecular Formula | C18H16Cl2N4O2 |
| CAS# | 354812-17-2 |
| Inchi | InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22) |
| Inchi Key | VVUOUIPXYFIWLE-UHFFFAOYSA-N |
| SMILES | C1CN(CC2=C1NC3=C2C(=CC(=C3Cl)Cl)C4=CN=C(C=C4)N)C(=O)CO |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/sc-514.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SC-514-chemical-structure-s4907.gif |