Ginsenoside Rb1
Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.
| Trivial name | Gypenoside Ⅲ |
| Catalog Number | S3924 |
| Molecular Formula | C23H35N9O8S |
| CAS# | 41753-43-9 |
| Inchi | InChI=1S/C23H35N9O8S/c1-11(34)32-4-2-3-17(32)23(40)29-14(5-12-7-26-10-27-12)20(37)30-15(8-33)21(38)31-16(9-41)22(39)28-13(19(25)36)6-18(24)35/h7,10,13-17,33,41H,2-6,8-9H2,1H3,(H2,24,35)(H2,25,36)(H,26 ,27)(H,28,39)(H,29,40)(H,30,37)(H,31,38)/t13-,14-,15-,16-,17-/m0/s1 |
| Inchi Key | MMHDBUJXLOFTLC-WOYTXXSLSA-N |
| SMILES | CC(=O)N1CCCC1C(=O)NC(CC2=CN=CN2)C(=O)NC(CO)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)N |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/ginsenoside-rb1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ginsenoside-rb1-chemical-structure-s3924.gif |