Harmine
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARĪ³ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
| Trivial name | Telepathine |
| Catalog Number | S3868 |
| Molecular Formula | C13H12N2O |
| CAS# | 442-51-3 |
| Inchi | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
| Inchi Key | BXNJHAXVSOCGBA-UHFFFAOYSA-N |
| SMILES | CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/harmine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/harmine-chemical-structure-s3868.gif |