Ensartinib dihydrochloride
Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.
| Trivial name | X-396 dihydrochloride |
| Catalog Number | S2934 |
| Molecular Formula | C11H10N2O2S |
| CAS# | 2137030-98-7 |
| Inchi | InChI=1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14) |
| Inchi Key | SYENTKHGMVKGAQ-UHFFFAOYSA-N |
| SMILES | C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ensartinib-dihydrochloride.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ensartinib-dihydrochloride-chemical-structure-s2934.gif |