NU7026
NU7026 (LY293646) is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. NU7026 enhances G2/M cell arrest and apoptosis.
| Trivial name | LY293646 |
| Catalog Number | S2893 |
| Molecular Formula | C22H21F2N3O |
| CAS# | 154447-35-5 |
| Inchi | InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 |
| Inchi Key | IKUFKDGKRLMXEX-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/nu7026.html |
| Additional Information | https://file.selleck.cn/downloads/struct/NU7026-chemical-structure-s2893.gif |