Bemcentinib (R428)

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).

Price Not Available 1mg Bemcentinib (R428) Supplier Page

Trivial name	BGB324
Catalog Number	S2841
Molecular Formula	C29H32F3N5O3
CAS#	1037624-75-1
Inchi	InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
Inchi Key	DJOVLOYCGXNVPI-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC=CC(=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
Size	1mg
Supplier Page	http://www.selleckchem.com/products/r428.html
Additional Information	https://file.selleck.cn/downloads/struct/s2841-bemcentinib-r428-chemical-structure.png