TPCA-1
TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.
| Trivial name | GW683965 |
| Catalog Number | S2824 |
| Molecular Formula | C12H10FN3O2S |
| CAS# | 507475-17-4 |
| Inchi | InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18) |
| Inchi Key | SAYGKHKXGCPTLX-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/tpca-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TPCA-1-chemical-structure-s2824.gif |