PF-04691502
PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.
| Trivial name | PF4691502 |
| Catalog Number | S2743 |
| Molecular Formula | C29H44N8O3 |
| CAS# | 1013101-36-4 |
| Inchi | InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34) |
| Inchi Key | GYQYAJJFPNQOOW-UHFFFAOYSA-N |
| SMILES | CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-04691502.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-04691502-chemical-structure-s2743.gif |