PF-04457845
PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.
| Trivial name | PF-4457845 |
| Catalog Number | S2421 |
| Molecular Formula | C26H30N6O3 |
| CAS# | 1020315-31-4 |
| Inchi | InChI=1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10,15-16,18,33H,4,11-14H2,1-3H3,(H,27,28,29) |
| Inchi Key | QAPAJIZPZGWAND-UHFFFAOYSA-N |
| SMILES | CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/pf-04457845.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-04457845-chemical-structure-s2421.gif |