PF-04457845
PF-04457845 (PF-4457845) is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily.
| Trivial name | PF-4457845 |
| Catalog Number | S2421 |
| Molecular Formula | C23H20F3N5O2 |
| CAS# | 1020315-31-4 |
| Inchi | InChI=1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32) |
| Inchi Key | BATCTBJIJJEPHM-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1=CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=NN=CC=C4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-04457845.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-04457845-chemical-structure-s2421.gif |