AMG-47a
AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
| Trivial name | N/A |
| Catalog Number | S2213 |
| Molecular Formula | C21H21ClF3N7O3S |
| CAS# | 882663-88-9 |
| Inchi | InChI=1S/C21H20F3N7O3S.ClH/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16;/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30);1H |
| Inchi Key | RQEBZJWSAAWCAV-UHFFFAOYSA-N |
| SMILES | CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/amg-47a.html |
| Additional Information | https://file.selleck.cn/downloads/struct/amg-47a-chemical-structure-s2213.gif |