AMG-47a
AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
| Trivial name | N/A |
| Catalog Number | S2213 |
| Molecular Formula | C21H18N4O4S |
| CAS# | 882663-88-9 |
| Inchi | InChI=1S/C21H18N4O4S/c1-2-29-21(26)19-13-23-20-9-8-15(14-25(19)20)16-10-17(12-22-11-16)24-30(27,28)18-6-4-3-5-7-18/h3-14,24H,2H2,1H3 |
| Inchi Key | SEKOTFCHZNXZMM-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CN=C2N1C=C(C=C2)C3=CC(=CN=C3)NS(=O)(=O)C4=CC=CC=C4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/amg-47a.html |
| Additional Information | https://file.selleck.cn/downloads/struct/amg-47a-chemical-structure-s2213.gif |