KRN 633
KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell.
| Trivial name | N/A |
| Catalog Number | S1557 |
| Molecular Formula | C20H21ClN4O4 |
| CAS# | 286370-15-8 |
| Inchi | InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26) |
| Inchi Key | VPBYZLCHOKSGRX-UHFFFAOYSA-N |
| SMILES | CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/KRN-633.html |
| Additional Information | https://file.selleck.cn/downloads/struct/KRN633-chemical-structure-S1557.gif |