Laduviglusib (CHIR-99021)
Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
| Trivial name | CT99021 |
| Catalog Number | S1263 |
| Molecular Formula | C22H18Cl2N8 |
| CAS# | 252917-06-9 |
| Inchi | InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) |
| Inchi Key | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/CHIR-99021.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CHIR99021-chemical-structure-s1263.gif |