Letrozole
Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.
| Trivial name | CGS 20267 |
| Catalog Number | S1235 |
| Molecular Formula | C19H17Cl2N3O2S |
| CAS# | 112809-51-5 |
| Inchi | InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2 |
| Inchi Key | GIEHIZKCIZLXLF-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/Letrozole.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Letrozole-chemical-structure-S1235.gif |