4-Hydroxyphenylacetic Acid attenuates inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. It’s also a reagent used in the acylation of phenols and amines. 4-Hydroxyphenylacetic Acid is a natural product isolated and purified from the herbs of Bulbophyllum odoratissimum, is active against the root-lesion nematode, Pratylenchus penetrans, and the pine wood nematode.