Spermine is a polyamine derived from spermidine by spermine synthase, functions as a free radical scavenger and forms a variety of adducts that prevent oxidative damage to DNA. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin and the prevention of endonuclease-mediated DNA fragmentation. Also used for nutritional supplementation and treatment of dietary shortage or imbalance.