10-Deacetylbaccatin III

Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3

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Catalog Number	CS-O-31076
Alternative Name(s)	10-Deacetylbaccatin III; (2aR,4S,4aR,6S,9S,11S,12S,12aR,12bS)-12,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dmetanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate; 92999-93-4;CS-T-51627
Molecular Formula	C29H36O1
CAS#	32981-86-5
Purity	>98%
SMILES	CC(O[C@@]1([C@](C[C@@H]2O)([H])OC1)[C@@]([C@@]2(C3=O)C)([H])[C@@H]([C@@](C4(C)C)(C[C@H](O)C(C)=C4[C@H]3O)O)OC(C5=CC=CC=C5)=O)=O
Size	500 g
Supplier Page	https://www.clearsynth.com/en/CSO31076.html