(-)-Epigallocatechin

(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils. IC50 value: Target: in vitro: EGCG is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that EGCG prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. EGCG exhibited a MIC and MBC of 5μg/mL and 20μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, EGCG induced significant down-regulation of E. faecalis virulence genes [3].

Price Not Available 10mM/1mL (-)-Epigallocatechin Supplier Page
Trivial name (-)-Epigallocatechin
Catalog Number HY-N0225
Alternative Name(s) EGC;Epigallocatechin;l-Epigallocatechin;epi-Gallocatechin
Research Area Others
CAS# 970-74-1
Purity ≥98%
Size 10mM/1mL
Supplier Page https://www.medchemexpress.com/_-_-Epigallocatechin.html