MK-8745 is an aurora A kinase inhibitor with IC50s of 0.6 nM. IC50 & Target: IC50: 0.6 nM (Aurora A)[1] In Vitro: MK-8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK-8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression[1]. 1 μM of MK-8745 exposure for 24 h induces cell cycle arrest in all NHL cells, with variable degrees of G2/M arrest. Z138C cells are highly sensitive to MK-8745 (1 μ M) treatment and induces an approximate 5.5-fold increase in the G2/M phase cell population by 96 h. MK-8745 treatment inhibits phosphorylation of Aurora-A in Granta 519 and Z138C cells, while Akata and JVM2 has no effect. MK-8745 specifically inhibits Aurora-A specific function. MK-8745 treatment leads to apoptotic cell death[2].

Price Not Available 50mg MK-8745 Supplier Page
Trivial name MK-8745
Catalog Number HY-13819
Research Area Cancer
CAS# 885325-71-3
Purity ≥98%
Size 50mg
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