(R)-CR8
(R)-CR8 is the second-generation analog of Roscovitine and a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p25, CDK7/cyclin H, CDK9/cyclin T and CK1δ/ε with IC50 of 0.09 μM, 0.072 μM, 0.041 μM, 0.11 μM, 1.1 μM, 0.18 μM and 0.4 μM, respectively. (R)-CR8 induces apoptosis and has neuroprotective effect.
Trivial name | CR8, (R-Isomer |
Catalog Number | S0735 |
CAS# | 294646-77-8 |
SMILES | CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4 |
Size | 2mg |
Supplier Page | http://www.selleckchem.com/products/r-cr8.html |