(-)-Epicatechin gallate

Epicatechin gallate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. IC50 & Target: IC50: 7.5 uM (COX-1)[1] In Vitro: Epicatechin gallate exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1]. In Vivo: Epicatechin gallate ((-)-Epicatechin-3-O-gallate, ECG), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg[2].

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Trivial name (-)-Epicatechin gallate
Catalog Number HY-N0002
Alternative Name(s) ECG;Epicatechin gallate;(-)-Epicatechin 3-O-gallate
Research Area Cancer
CAS# 1257-08-5
Purity ≥98%
Size 5mg
Supplier Page https://www.medchemexpress.com/_-_-Epicatechin-gallate.html